Ynte Ruigrok

Ruigrok foto nieuw

Dr. Ynte Ruigrok

  • stroke
  • genetic risks
  • from research to care
telefoon
+31 88 75 50462
email
ij.m.ruigrok@umcutrecht.nl

Biography

Ynte Ruigrok obtained her medical degree in Utrecht in 1999. After that she started working as a resident in Neurology at the Department of Neurology and neurosurgery of the University Medical Center Utrecht. She combined her residency with a PhD project on the genetics of intracranial aneurysm and aneurysmal subarachnoid hemorrhage. She has contributed to the identification of genetic risk factors of intracranial aneurysms using different approaches such as candidate gene studies, linkage studies, genome wide association studies (GWAS) and genome wide expression (GWE) studies. She has participated in three GWAS on intracranial aneurysms published in Nature Genetics. In 2006 she obtained her PhD degree cum laude. In 2010 she registered as a neurologist and continued working as a neurologist at the Department of Neurology and neurosurgery of the University Medical Center Utrecht. For her research she has received several prestigious grants, including a personal NWO-Veni grant in 2009 and a NWO- Clinical fellowship in 2014. Her current research focuses on the identification of 1) genetic determinants and biomarkers in the development and rupture of intracranial aneurysms and 2) first-degree relatives of aneurysm patients who are at high risk of developing aneurysms. For the research on the identification of genetic determinants and biomarkers she is involved in the identification of the functional mechanisms of the GWAS loci, the identification of new genetic risk factors and biomarkers for intracranial aneurysms . For the research on the identification of first-degree relatives of aneurysm patients she is performing epidemiological studies including follow-up studies and clinical decision modeling studies. She has 55 publications on the subject in high impact journals, of which 21 as fist author, 6 as last author, and an h index of 17.

Research line and group

Research line
Genetic riks of stroke
Number of PhD students
N=3

Personal fellowships and awards

  • 2014 Clinical fellowship, Netherlands Organization for Scientific Research (NWO)
  • 2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht
  • 2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’
  • 2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)
  • 2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)

Most recent key publications

  • Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet. 2010;42:420-5.
  • K. Bilguvar, K. Yasuno, M. Niemela, Y.M. Ruigrok, et al. Identification of susceptibility loci for intracranial aneurysm. Nat Genet 2008;40:1472-7
  • Y.M. Ruigrok, C. Wijmenga, G.J.E. Rinkel, R. van ’t Slot, F. Baas, M. Wolfs, A. Westerveld, Y.B.W.E.M. Roos. Genome-wide linkage in a large Dutch family with intracranial aneurysms: replication of two loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke 2008;39:1096-1102.
  • Y.M. Ruigrok, G.J.E. Rinkel. Genetics of intracranial aneurysms. Stroke 2008;39:1049-55.
  • Y.M. Ruigrok, G.J.E. Rinkel, R. van ’t Slot, M. Wolfs, S. Tan, C. Wijmenga. The contribution of genes involved in the maintenance of the extracellular matrix of the arterial wall to the development of intracranial aneurysms. Hum Mol Genet 2006; 15:3361-8