Pierre de Graan


Dr. Pierre de Graan

  • epilepsy
  • translational research
+31 88 7561234
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Pierre de Graan obtained his PhD degree in Utrecht (1981) with Frans van de Veerdonk and Alex Eberle (dept. Biology). He did a post doc in the Institute of Molecular Biology (Utrecht University) and in the Kantonsspital Basel (University of Basel) working on MSH receptors. Between 1987 and 2000 he was appointed at Utrecht University first as assistant and later as associated professor investigating the function of growth-associated protein GAP-43 in the Gispen lab. Since 2000 he is associate professor at the dept. of Neuroscience and Pharmacology of the University Medical Center Utrecht.

His research focusses on the molecular mechanisms underlying epilepsy.  In a long-term collaboration with child neurologists and neurosurgeons he studies the relationship between childhood febrile seizures and temporal lobe epilepsy later in life in rodents and humans.  His research focusses on susceptibility genes for febrile seizures and temporal lobe epilepsy and employs state-of-the-art genetic, molecular and cellular approaches in mouse models and tissue, cerebral fluid and blood from patients operated to treat temporal lobe epilepsy.  His work is published in > 150 publications.  He is  coordinator of the track Experimental and Clinical Neuroscience of the research master Neuroscience and Cogntion.

Research line and group

Research line
Mechanisms of epileptogenesis
Number of PhD students
Number of postdocs

Personal fellowships and awards

  • Hoffmann-LaRoche Fellowship
  • Rudolf Magnus Award
  • Duth National Epilepsy Foundation grant

Most recent key publications

  • Notenboom, RGE, Hampson, DR, Jansen, GH, van Rijen, P, van Veelen, CWM, van Nieuwenhuizen, O and de Graan, PNE. Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. Brain 129, 96-107 (2006)
  • van Gassen, KLI, de Wit, M, Groot Koerkamp, MJA. Rensen, MGA, van Rijen, PC, Holstege, FCP, Lindhout, D and de Graan, PNE. Evidence for a role of the innate immunity in temporal lobe epilepsy. Epilepsia; 49, 1055-1065 (2008)
  • Kan, AA, van Erp, S, Deriujck, AAHA, de Wit, M, Hessel, EVS, O’Duibhir, E, de Jager, W, van Rijen, PC, Gosselaar, PH, de Graan, PNE and Pasterkamp. Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell.Mol.Life Sci. 69, 3127-3145 (2012 )
  • Hessel, EVS, van lith, HA, Wolterink-Donselaar, IG, de Wit, M, Hendrickx, DAE, Kas, MJH and de Graan, PNE. Mapping of an X-linked quantitave trait locus for febrile seizure susceptibility in mice. Epilepsia 53, 1399-1410 (2012).
  • Kan, AA, de Jager, W, de Wit, Heijnen, CJ, Van Zuiden, M, Ferrier, CH, van Rijen, P, Gosselaar, P, Hessel, EVS, van Nieuwenhuizen, O, de Graan, PNE. Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines. J.Neuroinflamation 9, 207, 2012