Nicolette Notermans

Nicolette Notermans

Dr. Nicolette Notermans

  • neuromuscular disorders
+31 88 755 1881


Nicolette Notermans  obtained her PhD degree on the clinical features and pathogenesis of Chronic Idiopathic Axonal Polyneuropathy (CIAP) and Polyneuropathy associated with Monoclonal Gammopathy of undetermined significance (MGUS) in Utrecht (1994). After her PhD she obtained several  grants (NWO, Prinses Beatrix foundation) to study the etiology of CIAP, polyneuropathy associated with MGUS and other immune-mediated neuropathies.

She has initiated several studies of large, national cohorts of patients with CIAP and MGUS, in close collaboration with haematologists throughout the country.


She is a member of the word-wide task force of vasculitic  neuropathy and MGUS neuropathy. As president of the Dutch neuromuscular research organization (ISNO), she organized the 7th annual conference of the World Muscle Society in 2002, in Rotterdam.


Since 2010, she is the director of the successful neuromuscular diseases residency program which attracts many residents from other teaching hospitals.

Research line and group

Research line
Number of PhD students

Personal fellowships and awards

  • Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis
  • NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS
  • ZonMw Netwerk grant (2001)
  • ZonMw Health care efficiency research grant (1999-2002)
  • NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis

Most recent key publications

  • Visser NA, Vrancken AF, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care. 2013 36(4):817-22.
  • Niermeijer JM, Fischer K, Eurelings M, Franssen H, Wokke JH, Notermans NC. Prognosis of polyneuropathy due to IgM monoclonal gammopathy: a prospective cohort study. Neurology. 2010 2;74(5):406-12.
  • Franssen H, Notermans NC. Length dependence in polyneuropathy associated with IgM gammopathy. Ann Neurol. 2006;59(2):365-71
  • Niermeijer JM, Eurelings M, van der Linden MW, Lokhorst HM, Franssen H, Fischer K, Teunissen LL, van den Berg LH, Schobben F, Wokke JH, Notermans NC. Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy. Neurol. 2007 3;69(1):50-9.
  • Notermans NC, Wokke JH, van den Berg LH, van der Graaf Y, Franssen H, Teunissen LL, Lokhorst HM. Chronic idiopathic axonal polyneuropathy. Comparison of patients with and without monoclonal gammopathy. Brain. 1996;119 ( Pt 2):421-7.