The focus of my research career has been on the frontal-striatal network and how it is affected by schizophrenia. I was the first to examine the neural correlates of proactive inhibition and to center on the role of the striatum. In my VENI research, I replicated my previous studies and extended them by using DTI and Transcranial Magnetic Stimulation (TMS) to test structural and causal functional connectivity of the frontal-striatal network. My inhibition task and reward task are now being used in several groups worldwide. For example, to investigate the functional consequences of HIV on the brain in South Africa, and in the AMC Amsterdam to show, for the first time, how deep brain stimulation (DBS) affects neural functioning in the striatum. The strategy of my investigations has always been to start with healthy control subjects, to learn how the frontal-striatal network normally functions and develops. Adding patient data then not only helps to understand that disorder, but also to the general understanding of how the brain operates. Good research also includes understanding the methods of investigation, in my case functional MRI (fMRI). Besides teaching students how to design optimal fMRI tasks, and how to analyze the data, I developed ways to remove cardiorespiratory noise form the fMRI signal. In addition, I developed new ways to calculate how reliable fMRI is when subjects are tested multiple times.