Manon Hillegers

Hillegers M.H.J. 007

Dr. Manon Hillegers

  • psychoses
  • genetic risks
  • environmental risks
+31 88 7558180
Ga naar LinkedIn profiel


Manon Hillegers is an adult and child and adolescent psychiatrist whose research focus is on the development of bipolar disorder and psychosis in youth at high genetic risk. From 1997, during her PhD application, she recruited a cohort of 140 children of a bipolar parent (bipolar offspring). After her doctorate in 2007 University of Groningen, the NWO TOP grant allowed her to perform the 12 year follow-up of this Dutch bipolar offspring cohort. This study is one of world’s longest and largest longitudinal bipolar offspring studies. With 77% follow-up, she was able to establish the trajectories of psychopathology and identify phenotypic risk profiles. Her interest in the underlying neurobiological substrate of prodromal symptoms of bipolar disorder has led to the collaboration with the immunology department of the Erasmus Medical Center. Since 2008 she is  the PI of the Utrecht site of the European research consortium MoodInflame. The focus of this grant in the offspring cohort is immunogenetics. Her research projects reflect her strong drive to move her  investigations towards the neurobiological mechanism of bipolar disorder and psychosis. Also, In 2007 she set up a high-risk outpatient clinic for youth at high genetic risk to develop a bipolar or psychotic disorder. This outpatient clinic and research projects are closely linked. 

Research line and group

Research line
Risk and prevention; offspring studies
Number of PhD students
Number of postdocs

Personal fellowships and awards

  • NARSAD personal independent investigator grant 2013
  • Ducht foundation for Mental Health, personal grant 2012
  • Seed money Youth and Identity, University Utrecht 2013 (Co-PI)
  • EU 7th framework program, Health. MOODINFLAME (subcontract PI) 2008
  • Talent grant Dynamics of Youth, University Utrecht 2014

Most recent key publications

  • Mesman E, Nolen WA, Reichart CA, Wals M, Hillegers MH. (2013)The Dutch bipolar offspring study; 12 year follow-up. Am J Psychiatry 2013; 10.1176/appi.ajp.2012.12030401
  • Padmos R, Hillegers MHJ (equal first authorship) Knijff EM, Vonk R, Bouvy A, Staal FJT, The influence of life events on first and recurrent admissions in bipolar disorder. Kemner SM, van Haren NE, Bootsman F, Eijkemans MJ, Vonk R, van der Schot AC, Nolen WA, Hillegers MH. Int J Bipolar Disord. 2015 Feb 25;3:6. doi: 10.1186/s40345-015-0022-4. eCollection 2015.
  • Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood. Mesman E, Hillegers MH, Ambree O, Arolt V, Nolen WA, Drexhage HA. Bipolar Disord. 2015 Feb;17(1):39-49. doi: 10.1111/bdi.12231. Epub 2014 Jul 17
  • Hillegers MHJ, Reichart CG, Wals M, Verhulst FC, Ormel J, Nolen WA. (2005). Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents. Bipolar Disorders. aug;7: (4) 344-50
  • Kupka RW, Hillegers MH (2012) Staging and profiling in bipolar disorders. Tijdschr. Psychiatr. 2012;54(11):949-56