Manon Hillegers is an adult and child and adolescent psychiatrist whose research focus is on the development of bipolar disorder and psychosis in youth at high genetic risk. From 1997, during her PhD application, she recruited a cohort of 140 children of a bipolar parent (bipolar offspring). After her doctorate in 2007 University of Groningen, the NWO TOP grant allowed her to perform the 12 year follow-up of this Dutch bipolar offspring cohort. This study is one of world’s longest and largest longitudinal bipolar offspring studies. With 77% follow-up, she was able to establish the trajectories of psychopathology and identify phenotypic risk profiles. Her interest in the underlying neurobiological substrate of prodromal symptoms of bipolar disorder has led to the collaboration with the immunology department of the Erasmus Medical Center. Since 2008 she is the PI of the Utrecht site of the European research consortium MoodInflame. The focus of this grant in the offspring cohort is immunogenetics. Her research projects reflect her strong drive to move her investigations towards the neurobiological mechanism of bipolar disorder and psychosis. Also, In 2007 she set up a high-risk outpatient clinic for youth at high genetic risk to develop a bipolar or psychotic disorder. This outpatient clinic and research projects are closely linked.