Maeike Zijlmans


Dr. Maeike Zijlmans

  • epilepsy


Maeike Zijlmans finished her PhD with honors in May 2011 (prof van Huffelen and prof Gotman). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. Another part of the thesis concerns quality of life and coping style in epilepsy.  In 2013 she will start her work as clinical researcher at the RMI together with a combined clinical and research position at Epilepsy Institute in the Netherlands Foundation (SEIN). Her research group, consisting of four PhD students and several master students, studies HFOs in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and she started up a prospective randomized controlled two-center trial comparing the use of visually identified HFOs to spikes during surgery (the HFO trial). In the mean time the group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Another part of the research group works on the non-invasive identification of HFOs with EEG and MEG so the biomarker can help understand several epileptic disorders and help with finding the diagnosis and treatment in people with epilepsy.

Research line and group

Research line
Diagnostics in epilepsy surgery
Number of PhD students

Personal fellowships and awards

  • ZonMW veni personal grant
  • BCRM young talent grant and prize
  • Dutch Epilepsy Foundation research grants (2011, 2015)
  • Hersenstichting prize for scientific work
  • Amsterdam Neurologists prize for clinical research

Most recent key publications

  • van 't Klooster MA, van Klink NE, Leijten FS, Zelmann R, Gebbink TA, Gosselaar PH, Braun KP, Huiskamp GJ, Zijlmans M. Residual fast ripples in the intraoperative corticogram predict epilepsy surgery outcome. Neurology 2015;85:120-8.
  • Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.
  • van 't Klooster MA, Zijlmans M, Leijten FS, Ferrier CH, van Putten MJ, Huiskamp GJ. Time-frequency analysis of single pulse electrical stimulation to assist delineation of epileptogenic cortex. Brain. 2011 Oct;134(Pt 10):2855-66
  • Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009
  • Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.