Maeike Zijlmans


Dr. Maeike Zijlmans

  • epilepsy


Maeike Zijlmans is a neurologist and associate professor and she works at the Stichting Epilepsie Instellingen Nederland (SEIN) and the Brain Center Rudolf Magnus. The research group of Maeike Zijlmans, consisting of a post-doctoral fellow, four PhD students and several master students, studies HFOs in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and initiated a prospective randomized controlled trial comparing the use of visually identified HFOs to spikes during surgery (the HFO trial). In the mean time the group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis. The ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Part of the research group works on the non-invasive identification of HFOs with EEG and MEG, so the biomarker can help understand several epileptic disorders and help with finding the diagnosis and treatment in people with epilepsy. Another interest of her is the effect of stress and coping in epilepsy. Maeike Zijlmans finished her PhD with honors in May 2011 (prof van Huffelen and prof Gotman). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery.

Research line and group

Research line
Diagnostics in epilepsy surgery
Number of PhD students
Number of postdocs

Personal fellowships and awards

  • ZonMW veni personal grant
  • BCRM young talent grant and prize
  • Dutch Epilepsy Foundation research grants (2011, 2015)
  • Hersenstichting prize for scientific work
  • L'Oreal UNESCO for women in science grant

Most recent key publications

  • van 't Klooster MA, van Klink NE, Zweiphenning WJE, Leijten FS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intra-operative ECoG. Ann Neurol 2017 in press.
  • van Klink NE, van 't Klooster MA, Leijten FS, Jacobs J, Braun KP, Zijlmans M. Ripples on rolandic spikes: a marker of epilepsy severity. Epilepsia 2016;57:1179-89.
  • Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.
  • van 't Klooster MA, Zijlmans M, Leijten FS, Ferrier CH, van Putten MJ, Huiskamp GJ. Time-frequency analysis of single pulse electrical stimulation to assist delineation of epileptogenic cortex. Brain. 2011 Oct;134(Pt 10):2855-66
  • Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53