Jurjen Luykx

Jurjen

Dr. Jurjen Luykx

  • developmental disorders
  • psychoses
  • genetic risks
telefoon
+31 88 7568638
email
j.luykx@umcutrecht.nl
 
http://www.dejongepsychiater.nl
 
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Biography

Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. Starting January 1st, 2013 he holds a staff position as a clinical psychiatrist and heads the emergency psychiatry unit at ZNA (Ziekenhuis Netwerk Antwerpen) in Antwerp, Belgium. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. His thesis was entitled ‘Determinants of neurotransmitters in cerebrospinal fluid and plasma’ and his supervisors were Professors Kahn and Ophoff. In this work he demonstrates how both hypothesis-driven and genome-wide approaches in healthy subjects deepen our understanding of endophenotypes relevant to the field of psychiatric genetics. Since January 1st, 2014 he has been heading the Psychiatric Genetics Program of the Human Neurogenetics Unit at the Brain Center Rudolf Magnus (BCRM). This dedicated research position and his clinical appointment at ZNA in Antwerp enable him to collect large datasets of patients and carry out next-generation sequencing (NGS) and other genotyping projects. The Human Neurogenetics Unit is headed by Professor Veldink, who has tremendous expertise in analyzing large datasets of genetic data, allowing several interdisciplinary genetic studies to be set up. Jurjen is country coordinator for several clinical trials in schizophrenia, e.g. a trial investigating predniolone augmentation in schizophrenia and EULAST (http://www.eulast.eu); he additionally leads the genetic part of that study (both whole-genome and targeted pharmacogenomics research topics). He is the daily supervisor of two PhD students and at the BCRM: one focuses on genetic pleiotropy and the other on the genetics of phenotypes related to clozapine use. He was awarded the Rudolf Magnus Young Talent Fellowship in December 2014, allowing him to perform additional targeted NGS projects in the near future. Postdoctoral researcher Raha Pazoki has been working under his supervision as of August 2015, focusing on NGS and GWAS projects. His current areas of focus include genetics of clozapine-related phenotypes, genetics of brain electrophysiologial measures, pharmacogenetics, genetic pleiotropy and cerebrospinal fluid research in psychiatry.

Research line and group

Research line
Psychiatric Genetics
Number of PhD students
N=3
Number of postdocs
N=1

Personal fellowships and awards

  • Rudolf Magnus Young Talent Fellowship (2014)
  • Early Career Investigator Award by the International Society of Psychiatric Genetics (2012)
  • European College of Neuropsychopharmacology (ECNP) Young Scientists Award (2012)

Most recent key publications

  • J.J. Luykx, S.C. Bakker et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015).
  • S.C. Fears, S. Service, … J.J. Luykx, … et al. Multi-system component phenotypes of bipolar disorder for genetic investigations of extended pedigrees (JAMA Psychiatry, 2014
  • J.J. Luykx, S.C. Bakker et al. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid (Molecular Psychiatry, 2014).
  • J.J. Luykx / A. Brouwer, L. van Boxmeer et al. NMDA-receptor coagonists in serum, plasma and cerebrospinal fluid of schizophrenia patients: A meta-analysis of case-control studies (Neurosci Biobehav Rev., 2013).
  • J.J. Luykx, C.H. Vinkers et al. A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid (Neuropsychopharmacology, 2012).