Jeroen Pasterkamp

Pasterkamp

Prof. Jeroen Pasterkamp

  • epilepsy
  • neuromuscular disorders
  • developmental disorders
  • translational research
  • structure and connections
telefoon
+31 88 768831
email
r.j.pasterkamp@umcutrecht.nl
 
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Biography

Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Brain Research and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the Brain Center Rudolf Magnus, where he is currently appointed as a professor of translational neuroscience.

 His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS) and epilepsy). This research concentrates on mouse models and humanized cell models (iPSC) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

 His work was published in leading journals such as Cell, Journal of Neuroscience, Nature, Nature Genetics, PNAS and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, and a Dan Nathans Young Investigator Award. He is a member of the Scientific Advisory board of the Dutch National Epilepsy Fund (NEF) and the Dutch Society for Developmental Biology. He organizes scientific meetings under the framework of the Royal Netherlands Academy of Arts and Sciences (KNAW), EMBO, and Utrecht Summerschool series.

 

Research line and group

Research line
Neural circuit development and Translational neuroscience
Number of PhD students
N=10
Number of postdocs
N=5

Personal fellowships and awards

  • VICI, 2015
  • VIDI, 2006
  • HFSP career development award, 2005
  • VENI, 2004
  • NWO Talent, 2000

Most recent key publications

  • Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. Shared senior authors.
  • 2. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.
  • Koppers M, Blokhuis AM, Westeneng HJ, Terpstra ML, Zundel CA, Vieira de Sá R, Schellevis RD, Waite AJ, Blake DJ, Veldink JH, van den Berg LH, Pasterkamp RJ C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits. Ann Neurol. 2015 Sep;78(3):426-38
  • Van Battum EY, Brignani S, Pasterkamp RJ. Axon guidance proteins in neurological disorders. Lancet Neurol. 2015 May;14(5):532-46
  • Schmidt ER, Brignani S, Adolfs Y, Lemstra S, Demmers J, Vidaki M, Donahoo AL, Lilleväli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ. Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron. 2014 Jul 16;83(2):372-87