The overall aim of my research is to understand the cause of ischemic stroke with a focus on the three P’s: Pipes (vessel and vessel walls), Perfusion (CBF and reserve capacity) and Parenchyma (brain tissue and tissue changes/infarcts). After my PhD in 2004 I have created a new research field with technical development and clinical applications of MR methods of cerebral perfusion (so called arterial spin labeling MRI) and intracranial vessel wall imaging. My original MR research is recognized by the international research field with European grants (FP7, Biocog; WP leader) and personal national excellence grants (ERC-StG, VIDI, VENI, Heart association, Technical Research Council), chairmanship of international (ISMRM) perfusion study group, steering committee member of Carotid Stenosis Triallists Collaboration (CSTC), invited lectures, reviews, white papers and book chapters. 22 of my publications are within international collaborations (including Johns Hopkins University and Vanderbilt University, USA). I have 25 publications within the field of 7T MRI brain imaging method developments. In the radiology and neurovascular research arena ‘RADIOLOGY and ‘STROKE’ are leading journals: I have 28 publications in these journals. I am the first radiologist awarded with a VIDI grant and an ERC-StG. The focus of my research group is to understand the relation between the ‘3Ps’: Pipes (arterial vasculature), perfusion and parenchyma (brain tissue damage) by using innovative imaging methods.