Jaap Kappelle


Prof. Jaap Kappelle

  • stroke
+31 88 7557975


Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht and vice-chairmanof the trainings program for residents in neurology at the UMC Utrecht.

His research is embedded in the UMC Utrecht Stroke Centre in close collaboration with the departments of radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. The current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke.  Main research topics  are cognitive changes after stroke, intracranial vasculopathy, early diagnosis of ischaemic stroke, treatment of acute ischaemic stroke and management of patients with TIA’s in the posterior circulation. Jaap Kappelle serves as vice president of the board of scientific directors of The Netherlands Heart Foundation and is member elect of the European Stroke Council and the American Acadamy of Neurology. He is member of the board of directors of the Dutch Vascular Society and member of the scientific committee of ‘CardioVasculair Onderzoek Nederland’.

He has supervised 25 PhD students and is (co)author of about 400 peer reviewed publications or book chapters. His work was been cited about 17.000 times. His H-index is 49.

Research line and group

Research line
Cerebrovascular diseases
Number of PhD students

Personal fellowships and awards

  • Rudolf Magnus research Award, 1993
  • Jan Meerwald prijs (Dutch Society of neurology, 1994
  • A.C. Arntzenius prijs (Netherlands Heart Foundation, 1997)

Most recent key publications

  • Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB, for the HAMLET investigators. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol. 2009;8:326-333
  • Persoon S, Kappelle LJ, Klijn CJ. Limb-shaking transient ischaemic attacks in patients with internal carotid artery occlusion: a case-control study. Brain. 2010;133:915-922
  • Klijn CJ, Kappelle LJ. Haemodynamic stroke: clinical features, prognosis, and management. Lancet Neurol. 2010;9:1008-1017.
  • van Beijnum J, van der Worp HB, Buis DR, Al-Shahi Salman R, Kappelle LJ, Rinkel GJ, van der Sprenkel JW, Vandertop WP, Algra A, Klijn CJ. Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA. 2011;306:2011-9.
  • Luitse MJ, Biessels GJ, Rutten GE, Kappelle LJ. Diabetes, hyperglycaemia, and acute ischaemic stroke. Lancet Neurol. 2012;11:261-71.