Hilgo Bruining was trained as a pediatrician and a child and adolescent psychiatrist. He received his PhD in 2011 on the genetic dissection of behavioral phenotypes. Since 2011 he is a researcher en member of clinical staff at the departments of Psychiatry and Translational Neuroscience. Via his work on genetic mouse models and clinical experience he became interested in the role of inhibitory defects and sensory processing in autism. He has started the first integral clinical and research care program specifically focused on sensory processing disorders in autism. In this program, a variety of strategies (sensory behavioral and cognitive profiling, resting-state EEG and event related potentials) to unravel the link between sensory processing disorders, E/I imbalances and (social) behavioral problems. Part of this program involves the testing of novel medicinal strategies targeted to rebalance neuronal activity and GABAergic inhibition in particular. In addition, he collaborates on preclinical research programs to enhance translation of animal model findings to clinical studies and practice.