Hilgo Bruining

Hilgo Bruining


Hilgo Bruining was trained as a pediatrician and a child and adolescent psychiatrist. He received his PhD in 2011 on the genetic dissection of behavioral phenotypes. Since 2011 he is a researcher en member of clinical staff at the departments of Psychiatry and Translational Neuroscience. Via his work on genetic mouse models and clinical experience he became interested in the role of inhibitory defects and sensory processing in autism. He has started the first integral clinical and research care program specifically focused on sensory processing disorders in autism. In this program, a variety of strategies (sensory behavioral and cognitive profiling, resting-state EEG and event related potentials) to unravel the link between sensory processing disorders, E/I imbalances and (social) behavioral problems.  Part of this program involves the testing of novel medicinal strategies targeted to rebalance neuronal activity and GABAergic inhibition in particular. In addition, he collaborates on preclinical research programs to enhance translation of animal model findings to clinical studies and practice.

Research line and group

Research line
Neurodevelopmental disorders associated with Autism Spectrum Disorder
Number of PhD students

Personal fellowships and awards

  • 2015 ZonMW Rational Pharmacotherapy Program (GGG).
  • 2015 Stichting Michelle foundation Grant for research in Tuberous Sclerosis.
  • 2012 Annual research prize of the Dutch Association for Autism for best scientific contribution
  • 2012 EMBO short-term fellowship

Most recent key publications

  • van Campen S, Jansen FE, Kleinrensink, NJ, Joëls M, Braun KPJ, Bruining H. Sensory Modulation Disorders in Childhood Epilepsy. Journal of Neurodevelopmental Disorders, in press.
  • Bruining H, Passtoors L, Goriounova N, et al. Paradoxical benzodiazepine response: a rationale for bumetanide in neurodevelopmental disorders? Pediatrics, 2015.
  • Bruining H, Matsui A, Oguro-Ando A, Kahn R, et al. Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition, and sensorimotor development. Biological Psychiatry, 2015.
  • van Elst K, Bruining H, Birtoli B, Terreaux C, Buitelaar JK, Kas MJ. Food for thought: dietary changes in essential fatty acid ratios and the increase in autism spectrum disorders. Neurosci Biobehavioral Reviews. 2014.
  • van Diessen E, Senders J, Jansen FE, Boersma M, Bruining H. Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography. Eur Arch Psychiatry Clin Neurosci., 2014