Arjen Slooter

Slooter foto

Dr. Arjen Slooter

  • stroke
  • psychoses
  • from research to care
+31 88 75 61116


Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam (1986-1994) and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996) and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology in the UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined the UMC Utrecht where he is currently working as consultant neurologist-intensivist at the Department of Intensive Care Medicine.

Still fascinated by neuropsychiatry, his research focus is on delirium in ICU patients. He currently works on an EEG-based device to detect delirium, functional connectivity in delirium, drug side-effects and delirium, postoperative delirium, and long-term outcome after ICU admission. He is board member of the European Delirium Association. In addition, he is principal investigator of a multicentre trial on induced hypertension in subarachnoid haemorrhage patients with delayed cerebral ischemia, funded by Netherlands Brain Foundation and the Netherlands Heart Foundation.

The clinical focus of Arjen Slooter is on Intensive Care of neurological- and neurosurgical patients, and on neurological complications of critical illness. He is responsible for training of ICU nurses, residents and fellows in Neuro-Intensive Care in the UMC Utrecht. Arjen lives with wife Barbara, daughter Pien (2001) and son Bas (2004) in beautiful Utrecht.

Research line and group

Research line
Number of PhD students
Number of postdocs

Personal fellowships and awards

  • Annual Scientific Award, Society of Critical Care Medicine (2014).
  • EU-FP7 grant: ‘Biomarker development for postoperative cognitive impairment in the elderly’ (FP7-HEALTH-2013-Innovation-1, co-applicant).
  • Netherlands Heart Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’
  • Netherlands Brain Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2009)
  • ZonMW doelmatigheid: ‘Rivastigmine for delirium in Intensive Care patients, a multicentre, double-blind, randomised placebo-controlled add-on trial’

Most recent key publications

  • Slooter AJC. Critical illness, delirium and cognitive impairment. Nat Rev Neurol 2013. In press
  • Neto AS, Nassar AP Jr, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Damasceno MC, Slooter AJ. Delirium screening in critically ill patients: a systematic review and meta-analysis. Crit Care Med 2012;40:1946-51.
  • van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, van der Hoeven JG, Donders R, van Achterberg T, Schoonhoven L. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ 2012;344:e420
  • Van Eijk MM, van den Boogaard M, van Marum RJ, Benner P, Eikelenboom P, Honing ML, van der Hoven B, Horn J, Izaks GJ, Kalf, A, Karakus A, Klijn IA, Kuiper, MA, de Leeuw FE, de Man T, van der Mast RC, Osse R-J, de Rooij SEJA, Spronk PE, van der Voort, van Gool WA, Slooter AJ. Delirium assessment in daily critical care with the CAM-ICU: a multicenter study. Am J Respir Crit Care Med 2011;184:340-4
  • Van Eijk MMJ, Roes KCB, Honing MLH, Kuiper MA, Karakus A, van der Jagt M, Spronk PE, van Gool WA, van der Mast RC, Kesecioglu J, Slooter AJC. Rivastigmine does not decrease duration of delirium and may increase mortality in critically ill patients: a multicentre, double-blind, randomized, placebo-controlled add-on trial. Lancet 2010;376:1829-37